Some Gut Bacterial May Be Liable for the Development of Bowel Cancer, Study Finds

Some Gut Bacterial May Be Liable for the Development of Bowel Cancer, Study Finds


From the past few years, scientists have discovered links between bowel cancer and the gut microbiome. The new study offered at the National Cancer Research Institute (NCRI) conference is indicating there may be a causal link between a particular type of gut bacteria and an elevated risk of bowel cancer. The gut microbiome is a collection of various fungi, viruses, and bacteria present in our stomach or intestine. The large-scale trial concentrates on these tiny creatures residing in the gut of the human body, with researchers recommending some microbial structures could be linked to conditions ranging from anxiety to obesity.

Dr. Kaitlin Wade, a scientist at the University of Bristol, said they are attempting to make a lot with regards to prevent cancer. He added, despite the fact, the microbiome could be at play here is much higher, which is needed. As per Dr. Kaitlin, there is a need for interdisciplinary research to try and assist in this field. The finding, yet to peer-reviewed, consisted of Dr. Kailin and colleagues, seeking at the genetic and gut microbiome data. It included around 4,000 people across three European projects. The team has probed for the genetic variants linked to the existence of specific gut microbiota. The reason behind this is, such genetic variants are arbitrarily spread throughout the population; the approach is a type of natural experiment.

The researchers have discovered 13 genetic variants, each tie to variations in a separate type of gut bacteria. After that, they have analyzed another dataset consisting of around 2,000 people to know whether those with the genetic mutations had a massive tendency to develop bowel cancer. The results have shown people whose genes increased the probability of having Bacteoidales, a type of bacteria, had a 2-15% increased risk of the disease. The team has also said the findings support previous research claiming bacteria are more common in those with bowel cancer.

But as the genetic structure forms at the beginning of life, the study suggests these bacteria could be playing a crucial role in actually inducing bowel cancer. Dr. Kaitlin said still many questions remain unanswered, including whether the gut microbiomes are explicitly driving the increased risk of bowel cancer. He added they need to do more work to figure out how and why human genetic variation can transfer the gut microbiome.